Comparison ofl‐tyrosine containing dipeptides reveals maximum ATP availability forl‐prolyl‐l‐tyrosine in CHO cells
نویسندگان
چکیده
منابع مشابه
EXPRESSION OF HUMAN PROTEINASE 3 IN CHINESE HAMSTER OVARY CELLS (CHO-CELLS)
Proteinase 3(PR3) is a human polymorphonuclear leukocyte serine proteinase and is the main target antigen for antineutrophil cytoplasmic antibodies (ANCA) found in Wegener's granulomatosis (WG). We developed a stable expression system for conformationally intact recombinant PR3 (rPR3) in Chinese hamster ovary cells (CHO-cells). The part of PR3 cDNA that encoded the active form of PR3 was s...
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Pathological clot formation is the major cause of many serious diseases. A crucial step at the end of the coagulation cascade is the cleavage of soluble fibrinogen to fibrin clot by thrombin. A number of anticoagulants have been assessed clinically. Side effects such as excessive bleeding and difficulties of drug monitoring have led to considerable activity in the search of novel compounds with...
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Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory potency (IC(50)) values for Trp, Val-Trp and Trp-Val, which were about 200 time...
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ژورنال
عنوان ژورنال: Engineering in Life Sciences
سال: 2020
ISSN: 1618-0240,1618-2863
DOI: 10.1002/elsc.202000017